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KetoforCancer

Public • 252 • $14/m

18 contributions to KetoforCancer
What can inhibit Glutamine?
FROM CHAT GPT: Glutamine inhibition is often targeted in cancer therapy or metabolic research to restrict glutamine's role in cellular processes, especially since many tumors are glutamine-dependent. Here are some common approaches and compounds used for glutamine inhibition: 1. Glutaminase (GLS) Inhibitors: Glutaminase is an enzyme that converts glutamine into glutamate, a key step in glutamine metabolism. Inhibiting glutaminase can reduce glutamine availability for cell growth, especially in cancer cells. - CB-839 (Telaglenastat): One of the most well-known glutaminase inhibitors used in clinical trials for cancer therapy. - BPTES: An early inhibitor of GLS, although less potent than CB-839. 2. Glutamine Analogues: These are structural analogs of glutamine that can compete with glutamine for uptake and utilization in cells. - DON (6-Diazo-5-oxo-L-norleucine): A classic glutamine analog that inhibits multiple enzymes involved in glutamine metabolism. - Azaserine: Another glutamine analog that inhibits enzymes utilizing glutamine, particularly in nucleotide synthesis. 3. ASCT2 (SLC1A5) Inhibitors: ASCT2 is a glutamine transporter that facilitates the uptake of glutamine into cells. Blocking this transporter can limit glutamine's availability inside the cell. - V-9302: A small-molecule inhibitor targeting ASCT2, reducing glutamine uptake. 4. mTOR Inhibitors: Since glutamine can activate the mTOR pathway, which is crucial for cell growth and proliferation, mTOR inhibitors can indirectly affect glutamine metabolism. - Rapamycin (Sirolimus): An mTOR inhibitor that can be used to suppress the glutamine-driven mTOR signaling cascade. 5. GLUD (Glutamate Dehydrogenase) Inhibitors: GLUD converts glutamate (derived from glutamine) into α-ketoglutarate for use in the tricarboxylic acid (TCA) cycle. Inhibiting GLUD can reduce the energy and biosynthetic precursors provided by glutamine metabolism. 6. Inhibition of Amino Acid Synthesis Pathways:
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New comment 2h ago
1 like • 2h
@Miri Mo I will continue to research each item above to see if any more available than DON, which still might be the gold standard.
10 pass Ozone Therapy and Mitochondrial Health - Pub Med
Ozone high dose therapy (OHT) improves mitochondrial bioenergetics in peripheral blood mononuclear cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301618/ Conclusion: The worldwide increasing number of people with chronic diseases is pushing conventional therapy to its limits. The described multi-pass Major AutoHaemo Therapy has been used worldwide in many practices for years quite succesfully. So far, there has been no detailed explanation for the health-promoting properties of OHT. The results of the presented studies have shown that OHT can modulate mitochondrial functions. These studies lay the foundation for the further development of OHT as a safe and reliable method in combating a variety of chronic diseases in an area of precision medicine.
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New comment 51m ago
3 likes • 2d
@Candy Shackelford I read the articles and listen to podcasts, but not sure where it slots in the process of (1) rebuilding mitochondria (2) strengthening our immune system to better deal with cancer (3) eradicating pathogens which are involved with the whole model of origin of cancer (4) increasing ROS, and how it might help HBOT (5) increasing cognitive function. I’m sure there are more benefits, but these 5 have all been cited in the medical literature.
2 likes • 2h
Great result. I will definitely seek out providers in my area for the therapy.
New Member
Hi members. I am battling a spinal tumor that keeps regrowing after surgeries or radiation. I am interested to lean about the keto diet with the hope of stopping or slowing down further regrowth. To complicate matter I have been diagnosed with Fructose Mal absorption.Otherwise I am in good health.
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New comment 13h ago
1 like • 2d
@Rob Henderson Hi Rob, I’ve done therapeutic keto for several months and seen some of my spinal Mets go inactive (less than a 2.0 SUV rating after PET/CT scan), then added Tagrisso, a targeted drug specific to the EGFR marker/muttation, and had SBRT radiation last June on the 3 remaining tumors at T7,8 and L2, completely eradicating them as seen on recent rescan MRI of my full spine and PET/CT scan this week at MDA, in Houston. Hoverever, I developed more FDG active spots at T2, S2, occipital condyle, right iliac crest, and the primary nodule in my left upper lung lobe. Now I feel like I’m playing “wack-a-mole”, knowing that additional SBRT can eradicate them, but the present plan is to do a biopsy and run genetic testing for the 2nd time, looking to see if additional genetic markers, like the MET marker, can be identified, etc. This is all Standard Of Care (SOC), from my MDA docs, but I will continue on my keto diet, and redouble my efforts and repeat my HBOT sessions, having finished 40 a couple months ago. I got very encouraged the first few months as I saw regression of tumors as a applied Dr Seyfried’s protocol and did my 40 HBOT sessions. I won’t get discouraged, but as I continue to study and receive additional avenues of approach from all the folks in this group, I will keep moving forward. That is all any of us can do. I wrote to AlphaTau, and Dr. Robert Ben, who gave a podcast about the DART procedure that AlphaTau has developed in Israel, asking to be accepted into there clinical trial underway in Israel. All of our goal is to work toward remission and do whatever it takes to stay there. Helping each other by reciting the real truth of our efforts, positive and negative results, and asking questions is how we help each other. There are no dumb questions, and no one has “arrived”. It is a journey, a marathon, and an attempt to learn more about ourselves and the human condition. I am humbled by being the recipient of all the prayers offered up by so many people, and in return, I hope to be a source of strength, encouragement, and knowledge gained by other people, so that I can be a conduit of all I have received.
Breakthrough Cancer Treatment: Alpha Radiation Therapy by Dr. Robert Den
DART (Diffuse Alpha Radiation Therapy) is involved in clinical trials. Truly a Holy Grail in cancer treatment. https://www.youtube.com/watch?v=loRkgvaW2Y0
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New comment 2d ago
Breakthrough Cancer Treatment: Alpha Radiation Therapy by Dr. Robert Den
0 likes • 3d
Dr. Sanjay Juneja is a well-known podcaster, having interviewed Dr. Seyfried and many others. He is a triple-board certified oncologist based in Baton Rouge, LA. After listening to him, I will call to schedule an appointment. Even though I am being seen at MD Anderson, considered the #1 cancer research-based treatment center worldwide, I have not met a single doctor here that is conducive to metabolic treatment, but are all SOC adherents.
Supplement / Drug Poll: What do you suggest?
So as the basic information in the classroom is halfway done, on what other compound shall I focus to go into deep research on? Asked differently: Which compound do you think will bring the most "bang for your buck" when curing cancer? If available, post some research on the substrate, humans studies in vivo would of course would be best, although they won't be without soc / will not have been made with the patients in ketosis, I guess. So, what is your favorite? :-p
Poll
25 members have voted
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New comment 2d ago
2 likes • 4d
@Maup Enthoven About DRP-104 Our lead glutamine antagonist, DRP -104, is currently in early stage clinical development. The mechanisms of action for DRP-104 include: a) direct inhibition of tumor cell addiction to glutamine leading to substantial single agent activity and tumor regression; b) broad metabolic remodeling of the tumor microenvironment leading to enhanced anti-tumor immune activity; and, c) stimulation of T effector, NK and NKT cells and inhibition of immunosuppressive MDSC and macrophage cells, leading to greater long-term durable responses and survival. https://www.dracenpharma.com/dracen-announces-two-drp-104-presentations-at-aacr/
0 likes • 4d
@Maup Enthoven available for sale: https://www.selleckchem.com/products/sirpiglenastat.html
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Stuart Briscoe
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14points to level up
@stuart-briscoe-7909
74 y/o male, stage 4 NSCLC EGFR mutation, diagnosed 8/23 @MDA

Active 1h ago
Joined Aug 22, 2024
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